What is doxycycline used for

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Geriatric or debilitated patients. Such patients may be particularly susceptible to the sedative effects of benzodiazepines and associated giddiness, ataxia and confusion which may increase the possibility of a fall. Caution in the use of lorazepam is recommended in patients what is doxycycline used for respiratory depression.

In patients with chronic obstructive pulmonary disease, benzodiazepines can cause increased arterial carbon dioxide tension and decreased arterial oxygen tension. Lower doses should be used in elderly patients (see Section 4. Caution must be exercised in administering lorazepam what is doxycycline used for individuals known to be addiction prone or those whose history suggests they may increase the dosage on their own initiative.

It is what is doxycycline used for to limit repeat prescription without adequate medical supervision. The use of benzodiazepines may lead to dependence as defined what is doxycycline used for the presence of a withdrawal syndrome on discontinuation of the drug.

Withdrawal symptoms similar in character to those noted with barbiturates and alcohol have occurred following abrupt discontinuation of benzodiazepines. These symptoms can range from insomnia, anxiety, dysphoria, palpitations, panic attacks, vertigo, myoclonus akinesia, hypersensitivity to light, sound and touch, abnormal body sensations (e.

Such manifestations of withdrawal, especially the more serious ones, are more common in those patients who have received excessive doses over a prolonged period. However, withdrawal symptoms have also been reported following abrupt discontinuation of benzodiazepines taken continuously at therapeutic levels. Accordingly, Lorazepam should be terminated by tapering the dose to minimise occurrence of withdrawal symptoms. Patients should be advised to consult with their physician before either increasing the dose or abruptly discontinuing the medication.

Rebound phenomena have been described in the context of benzodiazepine use. Rebound insomnia and anxiety mean an increase in the severity of these symptoms beyond pre-treatment levels following cessation of benzodiazepines. Rebound phenomena in general possibly reflect re-emergence of pre-existing symptoms combined with withdrawal symptoms described earlier.

Some patients prescribed benzodiazepines with very short half-lives (in the order of 2 to 4 hours) may experience relatively mild rebound symptoms in between their regular doses. The safety and effectiveness of lorazepam has not been established in children less than 16 years of age. No interference with laboratory tests have been identified or reported with the use of lorazepam.

The benzodiazepines, including lorazepam, produce additive CNS depressant effects when co-administered with other medications which themselves produce CNS depression, e. The cytochrome P450 system has not been shown to be involved in the disposition of lorazepam and, unlike many benzodiazepines, pharmacokinetic interactions involving the P450 system have not been observed with lorazepam. The anticholinergic effects of other drugs including atropine and similar drugs, antihistamines and antidepressants may be potentiated.

Interactions have been reported between some what is doxycycline used for and anticonvulsants, with changes in the serum what is doxycycline used for of the benzodiazepine or anticonvulsant. It is recommended that patients be observed for altered responses when benzodiazepines and anticonvulsants are prescribed together, and that serum level monitoring of the anticonvulsant be performed more frequently.

Minor EEG changes, usually low voltage fast activity, of no known clinical significance, have been reported with benzodiazepine administration.

Continuous treatment during pregnancy and administration of high doses in connection with delivery should be avoided. Withdrawal symptoms in newborn infants have been reported with this class of drugs. The use of benzodiazepines during the first trimester of pregnancy should almost always be avoided. If the drug is prescribed to a woman of child-bearing potential, she should be warned to contact her physician regarding discontinuation of the drug if she intends to become or suspects that she is pregnant.

Neonates appear to conjugate lorazepam slowly, the glucuronide being detectable in the urine for more than seven days. Glucuronidation of lorazepam may competitively inhibit the conjugation of bilirubin, leading to hyperbilirubinaemia in the new born.

The use of benzodiazepines during the late phase of pregnancy or at delivery may require ventilation of the infant at birth. Caution should be exercised when lorazepam is given to breast feeding women. Lorazepam is excreted in human breast milk and may cause drowsiness and feeding difficulties in the infant. The more common adverse reactions, if they occur, are usually observed at the beginning of therapy and generally decreases in severity or disappears on continued medication or upon decreasing the dose.

Anterograde amnesia, dizziness, sedation. Disorientation, headache, sleep disturbances. Paradoxical reactions such as stimulation, excitement or rage rarely occur (see Section 4. Overdosage of benzodiazepines is usually manifested by degrees of central nervous system depression ranging from drowsiness to coma. In mild cases, symptoms include drowsiness, mental confusion and lethargy.

In more serious cases, symptoms may include ataxia, hypotonia, hypotension, respiratory depression, coma, and very rarely proves fatal. In the management of overdosage with any medication, it should be borne in mind that what is doxycycline used for agents may have been taken. Following overdosage with oral benzodiazepines, vomiting should be induced (within one hour) if the patient is conscious or gastric lavage undertaken with the airways protected if the patient is comatose.

If there is no advantage in emptying the stomach, activated charcoal should be given to reduce absorption. Hypotension and respiratory depression should be managed according to general principles. Haemoperfusion and haemodialysis are not useful in benzodiazepine intoxication. The benzodiazepine antagonist flumazenil may be used in hospitalised patients for the reversal of acute benzodiazepine effects.

Please consult the flumazenil product information prior to usage. For information on the management of overdose, contact the Poisons Information Centre on 131126 (Australia). Benzodiazepines presumably exert their effects by binding to specific receptors at several sites within the central nervous Femtrace (Estradiol Acetate Tablets)- Multum either by potentiating the effects of synaptic or roche covid test inhibition mediated by gamma-aminobutyric acid or by directly affecting the action potential generating mechanisms.

Lorazepam is readily absorbed when given orally. Peak concentrations in plasma occur approximately 2 hours following administration. The half-life of lorazepam in human plasma is approximately 12-16 what is doxycycline used for. The plasma levels of lorazepam are proportional to the dose given.

There is no evidence of excessive accumulation of lorazepam on administration up to 6 months nor is there any indication of induction of drug-metabolising enzymes under these conditions. Lorazepam is not what is doxycycline used for substrate for N-dealkylating enzymes of the cytochrome P450 system nor is it hydroxylated to any significant extent.

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